1246845-71-5Relevant academic research and scientific papers
Method for synthesizing 3-aryl substituted indolizine
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Paragraph 0024; 0025; 0026; 0027, (2017/10/27)
The invention discloses a method for synthesizing 3-aryl substituted indolizine. The method comprises the following steps: in an ionic liquid medium, performing in-situ generation of a bromination aryl methyl substituted pyridine quaternary ammonium salt from pyridine and aryl methyl bromide, and further performing 1,3-dipolar-cycloaddition reaction with electron-deficiency alkyne under an alkali condition, so as to obtain a target product. Compared with a conventional synthesis method, the method has the remarkable advantages that firstly, reaction conditions are simple, and no transition metal catalyst is used; secondly, reaction conditions are gentle, and reaction reagents are relatively safe and cheap; thirdly, the solvent used in the reaction is an ionic liquid which has the advantages of being low in steam pressure, not liable to combustion or explosion, recyclable and the like.
INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES
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Page/Page column 12, (2012/02/01)
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level and the like. That is, the present invention relates to indolizine derivatives represented by the following formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, salts thereof or the like. In the formula, ring U represents aryl or heteroaryl; R1 represents halogen, a hydroxy group or the like; R2 represents halogen, a hydroxy group, alkyl, alkoxy, alkyl substituted by fluorine, alkoxy substituted by fluorine or the like; m represents a number from 0 to 2; n represents a number from 0 to 3; and R3 represents hydrogen, fluorine or the like.
