124685-20-7

Upstream product

• 124685-23-0 1-[(3'R,4'R)-2',5',6'-trideoxy-6'-(diethoxyphosphinyl)-β-hexofuranosyl]thymine 
• 83467-48-5 1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 127218-27-3 (2S,3S,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydrofuran-2-carboxylic acid tert-butyl ester 
• 124685-23-0 1-[(3S,4R)-6-(diethoxyphosphinyl)-2,5,6-trideoxy-β-hexofuranosyl]thymine 
• 124685-25-2 (6'-diethoxyphosphonate-3'-O-methanesulphonyl-2',5',6'-trideoxy-β-D-lyxo-hexofuranosyl)-1-thymine 
• 127218-29-5 (6'-diethoxyphosphonate-3'-O-methanesulphonyl-2',5',6'-trideoxy-β-D-ribo-hexofuranosyl)-1-thymine 
• 127244-83-1 <6'-diethoxyphosphonate-3'-O-tert-butyldiphenylsilyl-6'-thio-(2'-pyridyl)-2',5',6'-trideoxy-β-D-ribo-hexofuranosyl>-1-thymine 
• 127218-28-4 (6'-diethoxyphosphonate-3'-O-tert-butyldiphenylsilyl-2',5',6'-trideoxy-β-D-ribo-hexofuranosyl)-1-thymine 
• 127244-82-0 (2S,3S,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydrofuran-2-carboxylic acid 
• 142802-32-2 (2R,4S,5R)-1-<4-azidotetrahydro-5-<2-(di-O-phenylphosphono)ethyl>-2-furyl>thymine 
• 142802-31-1 (E,2R,4S,5R)-1-<4-azidotetrahydro-5-<2-(di-O-phenylphosphono)vinyl>-2-furyl>thymine 
• 116786-62-0 3'-azido-3'-deoxy0thymidine-5'-aldehyde 
• 142802-33-3 (2R,4S,5R)-1-<4-azidotetrahydro-5-<2-(O-phenylphosphono)ethyl>-2-furyl>thymine 
• 124685-27-4 (3'-azido-6'-diethoxyphosphonate-2',3',5',6'-tetradeoxy-β-D-ribo-hexofuranosyl)-1-thymine 

Relevant academic research and scientific papers

New synthesis of sugar, nucleoside and α-amino acid phosphonates

Photolysis of N-hydroxy-2-thiopyridone esters derived from uronic acids of α-amino acids in presence of vinyl phosphonate affords the corresponding phosphonate derivatives. A convenient route for the synthesis of the isostere of AZT-5' monophosphate is de

3'-Azido-3', 5'-dideoxythymidine-5'-methylphosphonic Acid Diphosphate: Synthesis and HIV-1 Reverse Transcriptase Inhibition

3'-Azido-3'-deoxythymidine-5'-phosphonate was synthesized by five-step reaction sequence.The 5'-phosphonate was inactive against HIV-1 in MT4 cells.The absence of activity against HIV-1- was at least partially explained by demonstrating that the Km/