1246851-48-8

Basic information

• Product Name: 2-(p-tolyl)-4-(trifluoromethyl)pyridine
• Synonyms: 2-(p-tolyl)-4-(trifluoromethyl)pyridine
• CAS NO: 1246851-48-8
• Molecular Weight: 237.224
• Mol File: 1246851-48-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-(p-tolyl)-4-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(p-tolyl)-4-(trifluoromethyl)pyridine(1246851-48-8)
• EPA Substance Registry System: 2-(p-tolyl)-4-(trifluoromethyl)pyridine(1246851-48-8)

Safety Data

• Hazardous Substances Data: 1246851-48-8(Hazardous Substances Data)

Upstream product

• 3796-24-5 4-trifluoromethylpyridine 
• 5720-05-8 4-methylphenylboronic acid 
• 1448164-33-7 4-(trifluoromethyl)pyridine hydrochloride 
• 106-49-0 p-toluidine 
• 106-43-4 para-chlorotoluene 
• 106-38-7 para-bromotoluene 
• 5084-80-0 tri(4-tolyl)boroxine 

Relevant articles and documents

Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides

Pyridine rings are ubiquitous in drug molecules; however, the pre-eminent reaction used to form carbon-carbon bonds in the pharmaceutical industry, the Suzuki-Miyaura cross-coupling reaction, often fails when applied to these structures. This phenomenon is most pronounced in 2-substituted pyridines, and results from the difficulty in preparing, the poor stability of, and low efficiency in reactions of pyridine-2-boronates. We demonstrate that by replacing these boronates with pyridine-2-sulfinates, a cross-coupling process of unrivalled scope and utility is realized. The corresponding 3-And 4-substituted pyridine variants are also efficient coupling partners. In addition, we apply these sulfinates in a library format to the preparation of medicinally relevant derivatives of the drugs varenicline (Chantix) and mepyramine (Anthisan).

Phosphonium Salts as Pseudohalides: Regioselective Nickel-Catalyzed Cross-Coupling of Complex Pyridines and Diazines

Heterobiaryls are important pharmacophores that are challenging to prepare by traditional cross-coupling methods. An alternative approach is presented where pyridines and diazines are converted into heteroaryl phosphonium salts and coupled with aryl boronic acids. Nickel catalysts are unique for selective heteroaryl transfer, and the reaction has a broad substrate scope that includes complex pharmaceuticals. Phosphonium ions also display orthogonal reactivity in cross-couplings compared to halides, enabling chemoselective palladium- and nickel-catalyzed coupling sequences.

Direct arylation of n-heteroarenes with aryldiazonium salts by photoredox catalysis in water

A highly effective visible light-promoted "radical-type" coupling of N-heteroarenes with aryldiazonium salts in water has been developed. The reaction proceeds at room temperature with [Ru(bpy)3]Cl 2×6 H2O as a photosensit