1246851-74-0Relevant articles and documents
Direct C-H arylation of electron-deficient heterocycles with arylboronic acids
Seiple, Ian B.,Su, Shun,Rodriguez, Rodrigo A.,Gianatassio, Ryan,Fujiwara, Yuta,Sobel, Adam L.,Baran, Phil S.
supporting information; experimental part, p. 13194 - 13196 (2010/11/05)
A direct arylation of a variety of electron-deficient heterocycles with arylboronic acids has been developed. This new reaction proceeds readily at room temperature using inexpensive reagents: catalytic silver(I) nitrate in the presence of persulfate co-oxidant. The scope with respect to heterocycle and boronic acid coupling partner is broad, and sensitive functional groups are tolerated. This method allows for rapid access to a variety of arylated heterocycles that would be more difficult to access with traditional methods.