1246853-14-4Relevant academic research and scientific papers
Structural investigation of the binding of 5-substituted swainsonine analogues to golgi α-mannosidase II
Kuntz, Douglas A.,Nakayama, Shinichi,Shea, Kayla,Hori, Hitoshi,Uto, Yoshihiro,Nagasawa, Hideko,Rose, David R.
, p. 673 - 680 (2010)
Golgi α-mannosidase II (GMII) is a key enzyme in the N-glycosylation pathway and is a potential target for cancer chemotherapy. The natural product swainsonine is a potent inhibitor of GMII. In this paper we characterize the binding of 5α-substituted swai
