1246861-72-2Relevant academic research and scientific papers
AuI-catalyzed direct hydroamination/hydroarylation and double hydroamination of terminal alkynes
Patil, Nitin T.,Lakshmi, Pediredla G.V.V.,Singh, Vipender
experimental part, p. 4719 - 4731 (2010/10/21)
An efficient method for formal Markownikoff hydroamination/hydroarylation and double hydroamination of terminal alkynes has been developed. For example, treatment of terminal alkynes with amino-aromatics or diamines in the presence of 2-5 mol-% of Ph3PAuNTf2 in toluene at 100°C gave the corresponding products in excellent yields. The method was shown to be applicable to a broad range of substrates and, more importantly, unlike our previously reported method, a tethered hydroxy group in the alkyne is not necessary. The mechanism of the reaction is also discussed.
