1246875-40-0Relevant academic research and scientific papers
Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1β converting enzyme (ICE or caspase 1)
Galatsis, Paul,Caprathe, Bradley,Gilmore, John,Thomas, Anthony,Linn, Kristin,Sheehan, Susan,Harter, William,Kostlan, Catherine,Lunney, Elizabeth,Stankovic, Charles,Rubin, John,Brady, Kenneth,Allen, Hamish,Talanian, Robert
scheme or table, p. 5184 - 5190 (2010/10/02)
Succinic acid amides have been found to be effective P2-P3 scaffold replacements for peptidic ICE inhibitors. Heteroarylalkyl fragments occupying the P4 position provided access to compounds with nM affinities. Utilization of an acylal prodrug moiety was
