124691-89-0Relevant academic research and scientific papers
Synthesis and antiviral study of acyclic analogs of 3'-azido, 3'-amino, and 3'fluoro-3'-deoxythymidine, and HEPT analogs
Trinh,Florent,Grierson,Monneret
, p. 939 - 943 (1994)
Several new acyclonucleosides have been synthesized from racemic epichlorhydrin or epifluorhydrin. This involves epoxide opening followed by chain elongation with iodomethyl phenyl sulfide and subsequent coupling of the phenylthioacetal with thymine. Deprotection afforded the title compounds 6, (and 18, whereas introduction of a phenylthio group at C-6 led to the three HEPT analogs, 13, 19, and 24.
Solid-liquid phase transfer catalysis III: synthesis of azido acyclic nucleosides of pyrimidine
Lazrek, Hassan B.,Taourirte, Moha,Barascut, Jean-L.,Imbach, Jean-L.
, p. 19 - 24 (2007/10/03)
A series of novel azido acyclic nucleosides of pyrimidine derivatives were prepared using solid-liquid phase transfer catalysis (S.L.P.T.C) and tested as anti-HIV agents in cell assay.
