1246920-52-4Relevant academic research and scientific papers
A modular, stereoselective approach to spiroketal synthesis
Crimmins, Michael T.,Azman, Adam M.
supporting information; experimental part, p. 1489 - 1492 (2012/08/08)
A highly convergent and flexible synthetic approach to stereochemically defined spiroketals is reported. Substituents can be incorporated at various positions around the spiroketal framework without significant disruption to the synthetic scheme. The approach has been exploited to prepare the spiroketal fragment of milbemycin β Georg Thieme Verlag Stuttgart · New York.
Enantioselective total synthesis of spirofungins A and B
Crimmins, Michael T.,Obryan, Elizabeth A.
supporting information; experimental part, p. 4416 - 4419 (2010/11/18)
Figure Presented. The enantioselective total synthesis of spirofungins A (1) and B (2) is reported in 14 steps over the longest linear sequence. Key steps include the use of thiazolidinethione-mediated aldol reactions to assemble the major fragments and installation of the C1-C6 side chain using a cross metathesis reaction.
