1246929-24-7Relevant academic research and scientific papers
Synthesis and toxicity towards normal and cancer cell lines of benzimidazolequinones containing fused aromatic rings and 2-aromatic ring substituents
Moriarty, Eoin,Carr, Miriam,Bonham, Sarah,Carty, Michael P.,Aldabbagh, Fawaz
, p. 3762 - 3769 (2010)
A facile 6-exo-trig cyclization of σ-aromatic radicals has allowed the synthesis of various aromatic ring fused benzimidazoles and benzimidazolequinones. The most highly conjugated naphthyl fused benzimidazolequinone, (5-methyl-5,6-dihydrobenzimidazo[2,1-a]benzo[f] isoquinoline-8,11-dione) showed the highest specificity towards human cervical (HeLa) and prostate (DU145) cancer cell lines with little toxicity towards a human normal (GM00637) cell line at doses of a pyridine ring and mitomycin C were more toxic than the highly conjugated naphthyl fused benzimidazolequinone towards the normal cell line. The naphthyl fused benzimidazolequinone showed the highest specificity towards human cervical (HeLa) and prostate (DU145) cancer cell lines, with little toxicity towards a human normal (GM00637) cell line at doses of 1 μM.
