1246948-58-2

Upstream product

• 1246948-56-0 tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl][8-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate 

Downstream Products

• 1246948-60-6 tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl][8-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)octyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate 

Relevant academic research and scientific papers

Development of molecular probes for the human 5-HT6 receptor

In this work we report the synthesis of a set of labeled ligands targeting the human 5-HT6 receptor (h5-HT6R). Among the synthesized compounds, fluorescent probe 10 (Ki = 175 nM and -f = 0.21) and biotinylated derivative 15 (Ki = 90 nM) deserve special attention because they enable direct observation of the h5-HT6R in cells. Thus, they represent the first molecular probes for 5-HT6R visualization. These results are the starting point for introducing a variety of tags in these or other 5-HT6R ligand scaffolds aimed at the development of optimized probes with tailored profiles in terms of fluorescence, affinity, or selectivity.