1247023-34-2

Upstream product

• 1247023-16-0 N⁴-acetyl-3',5'-O-(tetraisopropyldisiloxane)-5-methyl-2'-O,4'-C-(N-methylaminomethylene)cytidine 
• 1247023-25-1 3',5'-O-tetraisopropyldisiloxane-5-methyl-2'-O,4'-C-(N-methylaminomethylene)cytidine 
• 1247023-20-6 3-N-benzoyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-4-methyl-2'-O,4'-C-(N-methylaminomethylene)uridine 
• 1247023-26-2 1-[3',5'-O-tetraisopropyldisiloxane-2'-O,4'-C-(N-methylaminomethylene)-β-D-ribofuranosyl]-5-methyl-4-(1,2,4-triazol-1-yl)pyrimidin-2-one 
• 1247023-19-3 N⁶-benzoyl-3',5'-O-(tetraisopropyldisiloxane)-2'-O,4'-C-(N-methylaminomethylene)adenosine 
• 4005-49-6 N₆-benzoyladenine 

Downstream Products

• 1247023-38-6 N⁶-benzoyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)adenosine 
• 1247023-36-4 N⁶-benzoyl-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)adenosine 

Relevant academic research and scientific papers

Direct and practical synthesis of 2′-O,4′-C-aminomethylene-bridged nucleic acid purine derivatives by transglycosylation

Purine nucleosides of 2′-O,4′-C-aminomethylene-bridged nucleic acid (BNANC) have been directly synthesized from pyrimidine BNANCusing transglycosylation reaction with high stereoselectivity and excellent yield. The BNANCpurine nucleosides (adenosine, guanosine, and inosine) prepared by the direct and practical procedure were derivatized to the corresponding phosphoramidites and were incorporated into DNA. A thermal denaturation study showed that BNANC-containing oligonucleotides hybridized to RNA selectively with excellent mismatch discrimination.

PROCESS FOR PRODUCING NUCLEOSIDE

There is a demand for a convenient production method of an NC type purine nucleoside. The present invention relates to a method of producing a purine nucleoside represented the formula (I') or a salt thereof, which comprising reacting a pyrimidine nucleoside represented by the formula (I) or a salt thereof with a purine nucleobase represented by the formula B'H in the presence of a Lewis acid.