124707-84-2Relevant academic research and scientific papers
Diastereoselective syn or anti opening of propargylic epoxides. Synthesis of α-allenic alcohols
Alexakis,Marek,Mangeney,Normant
, p. 1677 - 1696 (2007/10/02)
Propargylic epoxides easily react with Grignard reagents and catalytic amounts of copper(I) salt to afford α-allenic alcohols. The reaction is highly diastereoselective and its stereochemical outcome (syn or anti isomer) can be fully controlled. The syn d
DIASTEREOSELECTIVE SYNTHESIS OF α-ALLENIC ALCOHOLS FROM PROPARGYLIC EPOXIDES
Alexakis, A.,Marek, I.,Mangeney, P.,Normant, J.F.
, p. 2387 - 2390 (2007/10/02)
Tha cuprocatalyzed reaction of a Grignard reagent with propargylic epoxides proceed through an addition-elimination mechanism.By changing the reaction conditions, particularly the halogen atom of RMgX it is possible to control the diastereoselectivity of
