1247092-39-2

Upstream product

• 74315-08-5 N-acetyl-2-(2-bromophenyl)ethylamine 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 1307795-04-5 N-[2-(2-(4-bromo-3-[(1R,3'R)-5,6-difluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3'-yl]-5-isoxazolyl)phenyl)ethyl]acetamide 
• 1307796-07-1 tert-butyl (1R,3'R)-3'-(5-{2-[2-(acetylamino)ethyl]phenyl}-4-bromo-3-isoxazolyl)-5,6-difluoro-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate 
• 1247089-31-1 N-{2-[2-(bromoethynyl)phenyl]ethyl}acetamide 

Relevant academic research and scientific papers

SPIROCYCLIC PIPERIDINE DERIVATIVES USEFUL AS RENIN INHIBITORS

Renin inhibitors which are spirocyclic piperidine derivatives, of formula (I) and pharmaceutical compositions thereof useful in the treatment of cardiovascular diseases and renal insufficiency. or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of the stereoisomer thereof, wherein: n, for each instance in which it occurs, is independently 0, 1, or 2; W is a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic monocyclic ring, A is (i) a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic monocyclic ring or (ii) a first five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring which is fused to a second five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring, V is -(C=O)-, -CH2- or =CH-; U is a bond or -CH2-, or, when V iS =CH-, U is-CH=; X is =CH-, =CF-, =C(OR3)-, or -(C=O)-; and Y is =CH-, =CF-, =N-, or, for the case when X is -(C=O)-, Y is -N(R3)-.