124732-63-4Relevant academic research and scientific papers
Diastereoselective Ring-Opening Aldol-Type Reaction of 2,2-Dialkoxycyclopropanecarboxylic Esters with Carbonyl Compounds. 1. Synthesis of Cis 3,4-Substituted γ-Lactones
Shimada, Shigeru,Hashimoto, Yukihiko,Sudo, Atsushi,Hasegawa, Masaki,Saigo, Kazuhiko
, p. 7126 - 7133 (2007/10/02)
The Lewis-acid promoted reactions of 2,2-dialkoxycyclopropanecarboxylic esters 4a-c with aldehydes and unsymmetrical ketones to give γ-lactones were investigated.TiBr4 is an excellent catalyst and gives cis 3,4-substituted γ-lactones in good yields with h
Diastereoselective Synthesis of γ-Lactones by the Aldol-Type Reaction of Ethyl 2,2-Dialkoxycyclopropanecarboxylates with Aldehydes
Saigo, Kazuhiko,Shimada, Shigeru,Hashimoto, Yukihiko,Hasegawa, Masaki
, p. 1293 - 1296 (2007/10/02)
Ethyl 2,2-dialkoxycyclopropanecarboxylates, considered as three carbon 1,3-dipole equivalents, reacted smoothly with aldehydes in the presence of titanium(IV) bromide to give γ-lactones in good yields with high diastereoselectivity.
