1247462-49-2Relevant academic research and scientific papers
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: Identification of candidates for clinical development
Letavic, Michael A.,Aluisio, Leah,Atack, John R.,Bonaventure, Pascal,Carruthers, Nicholas I.,Dugovic, Christine,Everson, Anita,Feinstein, Mark A.,Fraser, Ian C.,Hoey, Kenway,Jiang, Xiaohui,Keith, John M.,Koudriakova, Tatiana,Leung, Perry,Lord, Brian,Lovenberg, Timothy W.,Ly, Kiev S.,Morton, Kirsten L.,Timothy Motley,Nepomuceno, Diane,Rizzolio, Michele,Rynberg, Raymond,Sepassi, Kia,Shelton, Jonathan
, p. 4210 - 4214 (2010)
The pre-clinical characterization of novel aryloxypyridine amides that are histamine H3 receptor antagonists is described. These compounds are high affinity histamine H3 ligands that penetrate the CNS and occupy the histamine H3 receptor in rat brain. Several compounds were extensively profiled pre-clinically leading to the identification of two compounds suitable for nomination as development candidates.
