124750-53-4Relevant articles and documents
Recycling and reuse technology for preparing triphenylchloromethane
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Paragraph 0067-0074, (2019/10/01)
The invention provides a recycling and reuse technology for preparing triphenylchloromethane. The technology comprises the following steps that hydrochloric acid or a mixture of the hydrochloric acidand Lewis acid is added into a solvent of triphenylcarbinol, stirring is conducted at a certain temperature, after a reaction is finished, separation is conducted, or after separation, recrystallization is further conducted, and the triphenylchloromethane is obtained after drying, wherein the reaction equation is shown in the description. The reuse technology is a recycling and reuse technology which is wide in raw material source, low in price and simple in production process operation and causes little pollution, and the technology is very suitable for commercialized production.
Method of ortho-arylation of special functional group on palladium/carbon catalytic benzene ring
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Paragraph 0029; 0030; 0031, (2017/07/14)
The invention discloses a method of ortho-arylation of a special functional group on a palladium/carbon catalytic benzene ring. The invention discloses a method of ortho-iodination of a special functional group on the palladium/carbon catalytic benzene ring. The method comprises the following steps: dissolving an aromatic ring with a substrate containing the special functional group, palladium/carbon as a catalyst, a hypervalent iodine agent and an alkaline substance into a solvent, carrying out reaction at the temperature of 80-120 DEG C for 5-12h, and after the reaction is completed, carrying out post-treatment on a reaction solution to obtain a substituted biphenyl product. The method has the advantages that the used method route cannot enable a great quantity of industrial waste water to be generated and is smaller in environmental pollution; a product obtained by reaction is high in yield and good in selectivity; and the used catalyst can be recycled and reused and has a potential industrial application value.
Bacterial Peptide Deformylase Inhibition of Tetrazole-Substituted Biaryl Acid Analogs: Synthesis, Biological Evaluations, and Molecular Docking Study
Khan, Firoz A. Kalam,Patil, Rajendra H.,Patil, Manjiri,Arote, Rohidas,Shinde, Devanand B.,Sangshetti, Jaiprakash N.
, p. 934 - 943 (2016/12/09)
The synthesis and screening of tetrazole-substituted biaryl acid analogs 7a–l as bacterial peptide deformylase (PDF) enzyme inhibitors is reported. The compounds 7e (IC50 value = 5.50 μM) and 7g (IC50 value = 7.25 μM) showed good PDF inhibition activity. The compounds 7e (MIC range = 10.75–11.66 μg/mL) and 7g (MIC range = 8.91–12.83 μg/mL) also showed potent antibacterial activity when compared with the standard ciprofloxacin (MIC range = 25–50 μg/mL). Thus, the active derivatives were not only potent PDF enzyme inhibitors but also efficient antibacterial agents. In order to gain more insight into the binding mode of the compounds with the PDF enzyme, the most active compounds 7e and 7g, the moderately active compound 7k, and the least active compound 7h were docked against the PDF enzyme of Escherichia coli. The docking study of the most active compounds 7e and 7g against the PDF enzyme exhibited good binding properties. Hence, we believe our synthesized compounds 7a–l could serve as reservoir for bacterial PDF inhibitor development.
