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4'-[(1H-benzimidazol-1-yl)-methyl]-N-(3,4-dimethyl-5-isoxazolyl)-N-((2-methoxyethoxy)methyl)-[1,1'-biphenyl]-2-sulfonamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1247725-75-2

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1247725-75-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1247725-75-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,7,7,2 and 5 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1247725-75:
(9*1)+(8*2)+(7*4)+(6*7)+(5*7)+(4*2)+(3*5)+(2*7)+(1*5)=172
172 % 10 = 2
So 1247725-75-2 is a valid CAS Registry Number.

1247725-75-2Relevant academic research and scientific papers

Synthesis and biological evaluation of 4′-[(benzimidazole-1-yl) methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists

Bai, Renren,Wei, Zhen,Liu, Jie,Xie, Weijia,Yao, Hequan,Wu, Xiaoming,Jiang, Jieyun,Wang, Qiujuan,Xu, Jinyi

, p. 4661 - 4667 (2012/09/07)

A series of 4′-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives (Ia-Il) were synthesized and biologically evaluated. It was found that Ig, the most active compound, antagonized both Ang II AT1 and endothelin ETA receptors (AT1 IC50 = 8.5, ETA IC50 = 8.9 nM), and was more potent than losartan in RHRs with no significant effect on heart rate. The preliminary structure-activity relationships were also discussed in the present paper.

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