124789-72-6

Upstream product

• 18171-56-7 bis(chloromethyl)(methyl)chlorosilane 
• 591-50-4 iodobenzene 
• 74-97-5 chlorobromomethane 
• 149-74-6 dichloromethylphenylsilane 

Downstream Products

• 138421-21-3 1,3-diacetoxy-2-methyl-2-phenyl-2-silapropane 
• 138421-16-6 1,3-disobutyryloxy-2-metyl-2-phenyl-2-silapropan-1-ol 
• 138421-14-4 2-phenyl-3-isobutyryloxy-2-methyl-2-silapropane-1-ol 
• 138421-14-4 2-phenyl-3-isobutyryloxy-2-methyl-2-silapropane-1-ol 
• 1622406-76-1 chloromethyl((2-iodophenoxy)methyl)(methyl)(phenyl)silane 
• 1622406-78-3 tert-butyl ((chloromethyl)(methyl)(phenyl)silyl)methyl(2-iodophenyl)carbamate 
• 1622406-80-7 C₁₉H₂₄ClIN₂O₂Si 
• 1622406-82-9 3-methyl-3-phenyl-3,4-dihydro-2H-1,3-benzooxasiline 
• 1622407-18-4 4-methyl-4-phenyl-3,4-dihydro-2H-benzo-1,4-oxasiline 
• 1622406-86-3 tert-butyl 3-methyl-3-phenyl-3,4-dihydropyrido[3,4-e][1,3]azasiline-1(2H)-carboxylate 
• 1622406-87-4 tert-butyl 3,3-diphenyl-3,4-dihydropyrido[3,4-e][1,3]azasiline-1(2H)-carboxylate 
• 1622407-22-0 tert-butyl 3-benzyl-3-phenyl-2,3-dihydro-1H-[1,3]azasilolo[4,5-c]pyridine-1-carboxylate 

Relevant academic research and scientific papers

3-Silaazetidine: An Unexplored yet Versatile Organosilane Species for Ring Expansion toward Silaazacycles

Small-ring silacycles are important organosilane species in main-group chemistry and have found numerous applications in organic synthesis. 3-Silaazetidine, a unique small silacycle bearing silicon and nitrogen atoms, has not been adequately explored due to the lack of a general synthetic scheme and its sensitivity to air. Here, we describe that 3-silaazetidine can be easily prepared in situ from diverse air-stable precursors (RSO2NHCH2SiR12CH2Cl). 3-Silaazetidine shows excellent functional group tolerance in a palladium-catalyzed ring expansion reaction with terminal alkynes, giving 3-silatetrahydropyridines and diverse silaazacycle derivatives, which are promising ring frameworks for the discovery of Si-containing functional molecules.

Anionic access to silylated and germylated binuclear heterocycles

A simple access to silylated and germylated binuclear heterocycles, based on an original anionic rearrangement, is described. A set of electron-rich and electron-poor silylated aromatic and heteroaromatic substrates were tested to understand the mechanism and the factors controlling this rearrangement, in particular its regioselectivity. This parameter was shown to follow the rules proposed before from a few examples. Then, the effect of the substituents borne by the silicon itself, in particular the selectivity of the ligand transfer, was studied. Additionally, this chemistry was extended to germylated substrates. A hypervalent germanium species, comparable to the putative intermediate proposed with silicon, seems to be involved. However, a pathway implicating the elimination of LiCH2Cl was observed for the first time with this element, leading to unexpected products of the benzo-oxa (or benzo-aza) germol-type.

Synthesis of optically active 2-sila-1,3-propanediols derivatives by enzymatic transesterification

Lipase from Candida cylindracea and lipase from Chromobacterium viscosum allowed the synthesis of silyl-chiral optically active compounds by mono-transesterification of 2-sila-1,3-propanediols.