124792-92-3

Upstream product

• 84784-38-3 α-(3,4-dimethoxyphenyl)-α-(methylthio)acetonitrile 
• 91-16-7 1,2-dimethoxybenzene 
• 60002-82-6 2-(3,4-dimethoxyphenyl)-2-(methylthio)-nitroethane 

Downstream Products

• 124792-93-4 N-<2-(3,4-dimethoxyphenyl)-2-(methylthio)ethyl>acetamide 
• 87293-17-2 (E)-N-<2-(3,4-dimethoxyphenyl)ethenyl>acetamide 

Relevant academic research and scientific papers

PHOSPHODIESTERASE IV INHIBITOR CONTAINING PYRIDYLACRYLAMIDE DERIVATIVE

This invention relates to a phosphodiesterase IV inhibitor containing as an active ingredient a pyridylacrylamide derivative represented by the following formula (I): (wherein Ar1 represents substituted or unsubstituted pyridyl; Ar2 represents phenyl substituted by alkoxy, etc.; R1 represents hydrogen, alkyl, or aryl; R2 represents hydrogen, alkyl, cyano, or alkoxycarbonyl; R3 represents hydrogen or optionally substituted alkyl; X represents oxygen or sulfur; A and B are the same or different and each independently represents hydrogen, hydroxyl, alkoxy, or alkylthio, or A and B together represent oxo, thioxo, etc., or A may be hydroxyl and B may be 1-alkylimidazol-2-yl; and n is an integer from 1 to 3) or a pharmaceutically acceptable salt thereof.

Compositions and methods for treating nephritis and inhibiting TGF -β related conditions using pyridylacrylamide derivatives

The present invention relates to an agent for treating nephritis and a TGF-β inhibiting agent comprising as an effective ingredient a pyridylacrylamide derivative represented by the following formula (I): wherein Ar1is a substituted or unsubstituted pyridyl group, Ar2is a substituted or unsubstituted phenyl group, R1is a hydrogen atom, an alkyl group or an aryl group, R2is a hydrogen atom, an alkyl group, a cyano group or an alkoxycarbonyl group, R3is a hydrogen atom or an optionally substituted alkyl group, X is an oxygen or sulfur atom, A and B are same or different and each represent a hydrogen atom, a hydroxyl group, an alkoxy group or an alkylthio group, or A and B together form an oxo or thioxo group, or a group represented by the formula: ═N—Y in which Y is a dialkylamino, hydroxyl, aralkyloxy or alkoxy group, or a group represented by the formula: —Z1—M—Z2— which Z1and Z2are same or different and each represent an oxygen or sulfur atom or an imino group optionally substituted by an alkyl group, and M is an alkylene group or a 1,2-phenylene group, or A is a hydroxyl group and B is a 1-alkylimidazol-2-yl group, and n is an integer of 1 to 3, or a pharmaceutically acceptable salt thereof; as well as the pyridylacrylamide derivatives.