1247952-67-5Relevant academic research and scientific papers
Highly stereoselective preparation of chiral α-Substituted sulfides from α-Chloro sulfides via 1,2-asymmetric induction
Raghavan, Sadagopan,Kumar, V. Vinoth,Chowhan, L. Raju
experimental part, p. 1807 - 1810 (2010/10/03)
A C-S stereogenic center is created with efficient stereocontrol by 1,2-asymmetric induction due to a vicinal C-O stereogenic center. Propargylic, allylic, and alkyl sulfides are readily prepared in good yield and stereoselectivity from α-chloro sulfides. The allylic sulfide have been converted to the corresponding sulfoxide/sulfilimine/sulfur ylide and subjected to [2,3]-sigmatropic rearrangement. The efficient 1,3-chirality transfer observed in this reaction eventually results in a net 1,4-chirality transfer. Georg Thieme Verlag Stuttgart.
