1247997-15-4

Upstream product

• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 4068-78-4 methyl 5-chloro-2-hydroxybenzoate 
• 1620300-90-4 methyl 5-chloro-2-(2-butyn-1-yloxy)benzoate 

Relevant academic research and scientific papers

Gold promoted arylative cyclization of alkynoic acids with arenediazonium salts

Alkynoic acids derived from salicylic acid and analogues undergo arylative cyclization with arenediazonium salts promoted by gold in the absence of external ligands. The reaction is thermally induced and proceeds even in the absence of light. A difference in regioselectivity has been found compared with that observed in the cycloisomerization process of the same type of compounds.

Silver(I) and gold(I)-promoted synthesis of alkylidene lactones and 2H-chromenes from salicylic and anthranilic acid derivatives

Ag(I) and Au(I) efficiently catalyze the cycloisomerization of terminal alkynoic acids into methylene seven-membered ring lactones. Depending on the metal, divergent reaction pathways were found for non terminal alkynoic acids. While Ag(I) led to lactones, Au(I) led to 2H-chromenes coming from the hydroarylation of the alkyne.