1248-42-6

Basic information

• Product Name: methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride
• Synonyms: methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride;PITOFENONEHYDROCHLORIDE(FORR&DONLY);2-[4-(2-piperidinoethoxy)benzoyl]benzoic acid methyl ester hydrochloride;methyl 2-[4-(2-piperidin-1-ylethoxy)benzoyl]benzoate hydrochloride;methyl 2-[4-(2-piperidin-1-ylethoxy)phenyl]carbonylbenzoate hydrochloride;Pitophenone hydrochloride
• CAS NO: 1248-42-6
• Molecular Formula: C₁₀H₁₆O₄
• Molecular Weight: 403.89914
• EINECS: 214-999-8
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1248-42-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 169-170°C
• Boiling Point: 512 °C at 760 mmHg
• Flash Point: 263.4 °C
• Appearance: /
• Vapor Pressure: 1.35E-10mmHg at 25°C
• Storage Temp.: -20°C Freezer
• CAS DataBase Reference: methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride(1248-42-6)
• EPA Substance Registry System: methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride(1248-42-6)

Safety Data

• Hazardous Substances Data: 1248-42-6(Hazardous Substances Data)

Usage

Description

Pitofenone is an antispasmodic agent and an inhibitor of acetylcholinesterase (AChE; Kis = 36 and 45 μM for bovine erythrocyte and electric eel enzyme, respectively). It inhibits acetylcholine-induced contractions of isolated guinea pig ileum when used at a concentration of 2.5 μM.

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 1248-42-6 differently. You can refer to the following data:
1. Diclofenac and its combination with Pitofenone and Fenpiverinium shows antispasmodic activity.
2. Diclofenac and its combination with Pitofenone and Fenpiverinium

InChI:InChI=1/C22H25NO4.ClH/c1-26-22(25)20-8-4-3-7-19(20)21(24)17-9-11-18(12-10-17)27-16-15-23-13-5-2-6-14-23;/h3-4,7-12H,2,5-6,13-16H2,1H3;1H

Upstream product

• 10334-26-6 (R)-camphorquinone 
• 16211-85-1 (1S)-3c-carboxy-2,2,3t-trimethyl-cyclopentane-r-carboperoxoic acid 
• 46365-22-4 (1R)-2-oxo-bornane-3endo-sulfonic acid 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 87859-84-5 (-)-(1R,3R)-3-chlorocamphoric anhydride 
• 560-07-6 (1S,3S)-(+)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid 
• 87798-59-2 (1R)-4ξ-bromo-1,2,2-trimethyl-cyclopentane-1r,3c-dicarboxylic acid 
• 20618-41-1 3-hydroxymethylcamphor 
• 13854-86-9 3-hydroxyimino-1,7,7-trimethylbicyclo<2,2,1>heptan-2-one Z-isomer 
• 59599-25-6 (1R)-(-)-cis-3-hydroxyisoborneol 
• 2792-42-9 (R,R)-camphor oxime 
• 464-49-3 (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one 
• 42931-10-2 1,7,7-trimethyl-3-methylene-norbornan-2-one 

Relevant articles and documents

An unexpected reaction of camphor with sodium metal

Reaction of camphor with sodium metal at elevated temperature in refluxing THF or toluene, furnishes an unexpected product. The product has been identified by spectral analysis and its structure confirmed by single crystal X-ray diffraction study. A preliminary mechanistic explanation has been suggested to explain this reaction.

Synthesis and characterization of Ru(II) and Ir(III) complexes that bear camphoric 1,3-diamine ligands

Two rigid N-monosulfonylated 1,3-diamine ligands have been prepared starting from commercially available d-camphor through three steps. Their reactions with [Ru(η6-arene)(μ-Cl)Cl]2 (arene = p-cymene or C6H5CO2Et) or [Ir(η 5-C5Me5)(μ-Cl)Cl]2 afforded five new complexes. The structures of one monosulfonamide 1,3-diamine ligand and three organometallic complexes were confirmed by X-ray crystallography.

Synthesis of 1,11,11-trimethyl-3,6-diazotricyclo [6.2.1.0 2,7]undeca-2,6-diene and 1,15,15-trimethyl-3,10-diazotetracyclo[10.2. 1.02,11.04,9]pentadeca-2,4(9),5,7,10-pentaene from camphoroquinone enantiomers

Optically active camphordihydro-2,3-pyrazine and camphorquinoxaline were prepared from camphoroquinone enantiomers. It was shown that (1S,4R)-(+)-camphoroquinone was formed by oxidation of (1S,3R, 4R)-(-)-3-bromocamphor and (1R,4S)-(-)-camphoroquinone from (1R,3S, 4S)-(+)-3-bromocamphor, respectively. Camphor anhydride was a side product (6-10%) of the reaction. Springer Science+Business Media, Inc. 2007.