124808-59-9Relevant academic research and scientific papers
Novel antagonists of the 5-HT3 receptor. Synthesis and structure-activity relationships of (2-alkoxybenzoyl)ureas
Bradley,Ward,White,Coleman,Taylor,Rhodes
, p. 1515 - 1520 (2007/10/02)
A series of benzoylureas derived from bicycle amines were prepared and evaluated for 5-HT3 antagonist activity on the rat isolated vagus nerve. From among these compounds, those analogues which were ortho substituted by an alkoxy group on the b
Heterocyclic compounds useful as 5-HT3 antagonists
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, (2008/06/13)
Aroyl ureas and carbamic acid derivatives of formula and pharmaceutically acceptable salts thereof wherein A is a specified aromatic radical including optionally substituted phenyl W is O or S Y is NH or S and B is a specified saturated azacyclic ring, eg tropan-3-yl or quinuclidin-3-yl, possess 5-HT3 -antagonistic activity and are, for example, useful in treatment of migraine, emesis, anxiety, gastro-intestinal disorders and as anti-psychotics.
