1248085-09-7

Basic information

• Product Name: C₁₀H₁₂BrFO₂
• Synonyms: C₁₀H₁₂BrFO₂
• CAS NO: 1248085-09-7
• Molecular Weight: 263.106
• Mol File: 1248085-09-7.mol

Chemical Properties

• CAS DataBase Reference: C₁₀H₁₂BrFO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₁₂BrFO₂(1248085-09-7)
• EPA Substance Registry System: C₁₀H₁₂BrFO₂(1248085-09-7)

Safety Data

• Hazardous Substances Data: 1248085-09-7(Hazardous Substances Data)

Upstream product

• 6482-24-2 2-Bromoethyl methyl ether 
• 77771-03-0 3-bromo-4-fluoro-benzyl alcohol 

Relevant articles and documents

Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists

Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, furanyl, thienyl, pyridyl, pyridyl N-oxide, oxazolyl or pyrrolyl, or cycloalkenyl R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; and Z is optionally substituted aryl or heteroaryl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.

2-Alkynyl-and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists

Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; R6 is H, alkyl, hydroxyalkyl or —CH2F; R7, R8 and R9 are H, alkyl, alkoxy, alkylthio, alkoxyalkyl, halo or —CF3; and Z is optionally substituted aryl, heteroaryl or heteroaryl-alkyl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.