1248276-34-7

Basic information

• Product Name: N-Cyclopropyl-5-fluoro-2-nitroaniline
• Synonyms: N-Cyclopropyl-5-fluoro-2-nitroaniline
• CAS NO: 1248276-34-7
• Molecular Formula: C₉H₉FN₂O₂
• Molecular Weight: 196.1783632
• Mol File: 1248276-34-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 329.7±32.0 °C(Predicted)
• Appearance: /
• Density: 1.461±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.39±0.20(Predicted)
• CAS DataBase Reference: N-Cyclopropyl-5-fluoro-2-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-Cyclopropyl-5-fluoro-2-nitroaniline(1248276-34-7)
• EPA Substance Registry System: N-Cyclopropyl-5-fluoro-2-nitroaniline(1248276-34-7)

Safety Data

• Hazardous Substances Data: 1248276-34-7(Hazardous Substances Data)

Usage

General Description

N-Cyclopropyl-5-fluoro-2-nitroaniline is a chemical compound with the molecular formula C9H8FNN2O2. It is an organic compound that contains a cyclopropyl group, a fluoro group, and a nitro group. N-Cyclopropyl-5-fluoro-2-nitroaniline is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in organic and medicinal chemistry research. N-Cyclopropyl-5-fluoro-2-nitroaniline has a wide range of applications in the chemical industry and plays an important role in the development of new drugs and agrochemical products.

Upstream product

• 446-35-5 2,4-Difluoronitrobenzene 
• 765-30-0 Cyclopropylamine 

Downstream Products

• 1251333-53-5 N²-cyclopropyl-4-fluorobenzene-1,2-diamine 
• 1356483-63-0 5-acetyl-N-[2-(cyclopropylamino)-4-fluorophenyl]pyridine-3-carboxamide 
• 1356483-65-2 N-[2-(cyclopropylamino)-4-fluorophenyl]-5-fluoropyridine-3-carboxamide 
• 347353-82-6 C₁₃H₁₈N₄O₂ 

Relevant articles and documents

INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES

Provided herein are heteroaryl inhibitors of fibroblast growth factor receptor kinases, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 (AeKir1) Channel

Mosquito-borne arboviral diseases such as Zika, dengue fever, and chikungunya are transmitted to humans by infected adult female Aedes aegypti mosquitoes and affect a large portion of the world's population. The Kir1 channel in Ae. aegypti (AeKir1) is an important ion channel in the functioning of mosquito Malpighian (renal) tubules and one that can be manipulated in order to disrupt excretory functions in mosquitoes. We have previously reported the discovery of various scaffolds that are active against the AeKir1 channel. Herein we report the synthesis and biological characterization of a new 2-nitro-5-(4-(phenylsulfonyl) piperazin-1-yl)-N-(pyridin-4-ylmethyl)anilines scaffold as inhibitors of AeKir1. This new scaffold is more potent in vitro compared to the previously reported scaffolds, and the molecules kill mosquito larvae.

METALLOENZYME INHIBITOR COMPOUNDS

Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.