124852-44-4

Basic information

• Product Name: (3-methyl-4,5-dihydroisoxazol-5-yl)(phenyl)methanone
• Synonyms: (3-methyl-4,5-dihydroisoxazol-5-yl)(phenyl)methanone
• CAS NO: 124852-44-4
• Molecular Weight: 189.214
• Mol File: 124852-44-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3-methyl-4,5-dihydroisoxazol-5-yl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3-methyl-4,5-dihydroisoxazol-5-yl)(phenyl)methanone(124852-44-4)
• EPA Substance Registry System: (3-methyl-4,5-dihydroisoxazol-5-yl)(phenyl)methanone(124852-44-4)

Safety Data

• Hazardous Substances Data: 124852-44-4(Hazardous Substances Data)

Upstream product

• 591-51-5 phenyllithium 
• 124852-46-6 3-Methyl-4,5-dihydro-isoxazole-5-carboxylic acid dimethylamide 
• 55134-82-2 methyl 3-methyl-4,5-dihydroisoxazole-5-carboxylate 
• 5667-47-0 phenacyldimethylsulfonium bromide 
• 102588-22-7 N,N-bis(trimethylsilyloxy)-1-propen-2-amine 

Relevant articles and documents

Synthesis of Isoxazolines from Nitroalkanes via a [4+1]-Annulation Strategy

A novel access to isoxazolines was developed using the [4+1]-annulation of α-keto-stabilized sulfur ylides with N,N-bis(siloxy)enamines derived from aliphatic nitro compounds. The resulting 5-keto-substituted isoxazolines were shown to be convenient precursors of polysubstituted 3-hydroxypyrrolidines via the one-pot catalytic N?O hydrogenolysis/intramolecular reductive amination sequence. Application of this approach to the formal synthesis of Merck's potent NK1 receptor antagonist was demonstrated. (Figure presented.).