1248520-97-9Relevant academic research and scientific papers
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases
Vonnussbaum, Franz,Li, Volkhart M.-J.,Allerheiligen, Swen,Anlauf, Sonja,B?rfacker, Lars,Bechem, Martin,Delbeck, Martina,Fitzgerald, Mary F.,Gerisch, Michael,Gielen-Haertwig, Heike,Haning, Helmut,Karthaus, Dagmar,Lang, Dieter,Lustig, Klemens,Meibom, Daniel,Mittendorf, Joachim,Rosentreter, Ulrich,Sch?fer, Martina,Sch?fer, Stefan,Schamberger, Jens,Telan, Leila A.,Tersteegen, Adrian
, p. 1163 - 1173 (2015/07/07)
Human neutrophil elastase (HNE) is a key protease for matrix degradation. High HNE activity is observed in inflammatory diseases. Accordingly, HNE is a potential target for the treatment of pulmonary diseases such as chronic obstructive pulmonary disease
SULFONIC AMIDE AND SULFOXIMINE-SUBSTTTUTED DIARYL-DIHYDROPYRIMIDINONES AND USAGE THEREOF
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, (2012/04/23)
The present application relates to novel sulfonamidw- or sulfoximine-substituted 1,4-diaryldihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and als
4-(4-CYANO-2-THIOARYL)DIHYDRO PYRIMIDINONES AND THEIR USE
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, (2011/02/26)
The present invention relates to novel 4-(4-cyano-2-thioaryl) dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing
