1248576-70-6 Usage
Description
(S)-6-(3-cyano-1-cyclobutyl-6-(difluoromethoxy)-1H-indol-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyridine-3-sulfonamide is a complex chiral molecule with a long molecular structure and multiple functional groups. It features a sulfonamide group, a pyridine ring, a trifluoropropan-2-yl group, a difluoromethoxy group, and a cyano group. The presence of these groups suggests potential pharmacological applications, as similar structures are often found in pharmaceutical compounds. The difluoromethoxy group may also indicate possible interactions with biological systems or use as a fluorination reagent.
Uses
Used in Pharmaceutical Industry:
(S)-6-(3-cyano-1-cyclobutyl-6-(difluoromethoxy)-1H-indol-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyridine-3-sulfonamide is used as a potential pharmaceutical compound for its various functional groups that may interact with biological systems. The presence of the indol-2-yl and pyridine-3-sulfonamide groups suggests potential applications in drug development, possibly targeting specific receptors or enzymes in the body.
Used in Chemical Research:
In the field of chemical research, (S)-6-(3-cyano-1-cyclobutyl-6-(difluoromethoxy)-1H-indol-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyridine-3-sulfonamide can be used as a starting material or a building block for the synthesis of other complex molecules. Its unique structure and functional groups make it an interesting candidate for further exploration and potential development of new compounds with specific properties or applications.
Used in Fluorination Reactions:
Due to the presence of the difluoromethoxy group, (S)-6-(3-cyano-1-cyclobutyl-6-(difluoromethoxy)-1H-indol-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyridine-3-sulfonamide may be used as a fluorination reagent in chemical reactions. This could be particularly useful in the synthesis of fluorinated compounds, which often have unique properties and are of interest in various fields, including pharmaceuticals, materials science, and agrochemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1248576-70-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,8,5,7 and 6 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1248576-70:
(9*1)+(8*2)+(7*4)+(6*8)+(5*5)+(4*7)+(3*6)+(2*7)+(1*0)=186
186 % 10 = 6
So 1248576-70-6 is a valid CAS Registry Number.
1248576-70-6Relevant articles and documents
Structure-activity relationship (SAR) optimization of 6-(Indol-2-yl) pyridine-3-sulfonamides: Identification of potent, selective, and orally bioavailable small molecules targeting hepatitis C (HCV) NS4B
Zhang, Nanjing,Zhang, Xiaoyan,Zhu, Jin,Turpoff, Anthony,Chen, Guangming,Morrill, Christie,Huang, Song,Lennox, William,Kakarla, Ramesh,Liu, Ronggang,Li, Chunshi,Ren, Hongyu,Almstead, Neil,Venkatraman, Srikanth,Njoroge, F. George,Gu, Zhengxian,Clausen, Valerie,Graci, Jason,Jung, Stephen P.,Zheng, Yingcong,Colacino, Joseph M.,Lahser, Fred,Sheedy, Josephine,Mollin, Anna,Weetall, Marla,Nomeir, Amin,Karp, Gary M.
, p. 2121 - 2135 (2014/04/03)
A novel, potent, and orally bioavailable inhibitor of hepatitis C RNA replication targeting NS4B, compound 4t (PTC725), has been identified through chemical optimization of the 6-(indol-2-yl)pyridine-3-sulfonamide 2 to improve DMPK and safety properties.
