1248587-63-4Relevant academic research and scientific papers
Palladium-catalyzed amination of unprotected halo-7-azaindoles
Henderson, Jaclyn L.,McDermott, Sarah M.,Buchwald, Stephen L.
supporting information; experimental part, p. 4438 - 4441 (2010/12/20)
Simple and efficient procedures for the Pd-catalyzed cross-coupling of primary and secondary amines with halo-7-azaindoles(pyrrolo[2,3-b]pyridine) are presented. Previously, no general method was available to ensure the highly selective reaction of the heteroaryl halide in the presence of the unprotected azaindole N-H. Using palladium precatalysts recently reported by our group, such reactions are easily accomplished under mild conditions that can be applied to cross-coupling reactions with a wide array of aliphatic and aromatic amines.
