124862-65-3Relevant academic research and scientific papers
Constructing a triangular metallacycle with salen-Al and its application to a catalytic cyanosilylation reaction
Li, Bo,Li, Yang,Qiu, Huayu,Xu, Jun,Yin, Shouchun,Zhang, Jinjin,Zhang, Pengfei,Zhang, Yueyue
, p. 10399 - 10402 (2021/10/12)
A triangular metallosalen-based metallacycle was constructed in quantitative yield by the self-assembly of a 180° bis(pyridyl)salen-Al complex and a 60° diplatinum(ii) acceptor in a 1?:?1 stoichiometric ratio. This metallacycle was then successfully used to cyanosilylate a wide range of benzaldehydes with trimethylsilyl cyanide.
MANUFACTURING METHOD OF 2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE AND PYRIMIDINE COMPOUND
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Paragraph 0032, (2019/02/24)
PROBLEM TO BE SOLVED: To provide a manufacturing method of 5-chloro-4-ethyl-6-[2-(4-trifluoromethylphenyl)ethylamino]pyrimidine having pest control efficiency and 2-[4-(trifluoromethyl)phenyl]ethylamine as a manufacturing intermediate thereof, in which th
An orthogonal biocatalytic approach for the safe generation and use of HCN in a multistep continuous preparation of chiral O-acetylcyanohydrins
Brahma, Aischarya,Musio, Biagia,Ismayilova, Uliviya,Nikbin, Nikzad,Kamptmann, Sonja B.,Siegert, Petra,Jeromin, Günter E.,Ley, Steven V.,Pohl, Martina
, p. 262 - 266 (2016/01/20)
An enantioselective preparation of O-acetylcyanohydrins has been accomplished by a three-step telescoped continuous process. The modular components enabled an accurate control of two sequential biotransformations, safe handling of an in situ generated hazardous gas, and in-line stabilization of products. This method proved to be advantageous over the batch protocols in terms of reaction time (40 min vs 345 min) and ease of operation, opening up access to reactions which have often been neglected due to safety concerns.
Enzymatic kinetic resolution of racemic cyanohydrins via enantioselective acylation
Xu, Qing,Xie, Yongli,Geng, Xiaohong,Chen, Peiran
supporting information; experimental part, p. 624 - 630 (2010/09/07)
Enzymatic kinetic resolution of a series of aromatic and aliphatic cyanohydrins in organic media has been investigated. The behavior of potential lipases, molecular sieves, acyl reagent, reaction temperature, and organic solvents on the kinetic resolution was studied. The influence of substrate structure, steric, and electronic nature and position of the aryl substituent on the enantioselectivity was discussed. Under the optimized reaction conditions, good enantioselectivity could be achieved for most of the investigated compounds. Specifically, substrates 1a, 1c, 1d, 1f, 1u could be resolved with the kinetic enantiomer ratio (E) higher than 200.
