124863-77-0

Upstream product

• 110-89-4 piperidine 
• 459-57-4 4-fluorobenzaldehyde 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 

Downstream Products

• 131000-91-4 6-Ethoxycarbonyl-5-(4-fluorophenyl)-7-isopropyl-1-methyl-2,4-dioxo-1,2,3,4,5,8-hexahydro-pyrido(2,3-d)pyrimidine 
• 131000-85-6 1-Butyl-6-ethoxycarbonyl-5-(4-fluorophenyl)-7-isopropyl-2,4-dioxo-1,2,3,4,5,8-hexahydro-pyrido(2,3-d)pyrimidine 

Relevant academic research and scientific papers

SUBSTITUTED 1,8-NAPHTHYRIDINES AND THEIR USE IN MEDICAMENTS

Inhibitors of 3-hydrooxy-3-methyl-glutarylcoenzyme A reductase which are 1,8-naphthyridines of the formula STR1 in which A represents a 3-to 7-membered heterocycle which is optionally substituted, or aryl which is optionally substituted,

HMG-CoA reductase inhibiting substituted pryido (2,3-d) pyrimidines

New substituted pyrido(2,3-d)pyrimidines of the formula STR1 can be prepared by reduction of corresponding pyrido(2,3-d)-pyrimidines which are substituted by a ketone radical, and subsequent hydrolysis, cyclization or hydrogenation. The new compounds can be used to inhibit HMG-CoA reductase.

Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals

Compounds of the formula STR1 and processes for and intermediates in the synthesis thereof, pharmaceutical compositions comprising such a compound and the use of such compounds for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis.