124863-82-7

Basic information

• Product Name: 3-TERT-BUTYLDIMETHYLSILYLOXYMETHYL-2,6-DIISOPROPYL-4-(4-FLUOROPHENYL)-5-HYDROXYMETHYL-PYRIDINE
• Synonyms: 3-TERT-BUTYLDIMETHYLSILYLOXYMETHYL-2,6-DIISOPROPYL-4-(4-FLUOROPHENYL)-5-HYDROXYMETHYL-PYRIDINE;5-[[[(1,1-DiMethylethyl)diMethylsilyl]oxy]Methyl]-4-(4-fluorophenyl)-2,6-bis(1-Methylethyl)-3-pyridineMethanol
• CAS NO: 124863-82-7
• Molecular Formula: C₂₅H₃₈FNO₂Si
• Molecular Weight: 431.6586232
• Product Categories: Aromatics Compounds;Aromatics;Bases & Related Reagents;Nucleotides;Aromatics, Nucleotides, Bases & Related Reagents
• Mol File: 124863-82-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 488.9°C at 760 mmHg
• Flash Point: 249.5°C
• Appearance: /
• Density: 1.019g/cm³
• Vapor Pressure: 2.26E-10mmHg at 25°C
• Refractive Index: 1.51
• Solubility: Acetone, Chloroform, Dichloromethane
• CAS DataBase Reference: 3-TERT-BUTYLDIMETHYLSILYLOXYMETHYL-2,6-DIISOPROPYL-4-(4-FLUOROPHENYL)-5-HYDROXYMETHYL-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-TERT-BUTYLDIMETHYLSILYLOXYMETHYL-2,6-DIISOPROPYL-4-(4-FLUOROPHENYL)-5-HYDROXYMETHYL-PYRIDINE(124863-82-7)
• EPA Substance Registry System: 3-TERT-BUTYLDIMETHYLSILYLOXYMETHYL-2,6-DIISOPROPYL-4-(4-FLUOROPHENYL)-5-HYDROXYMETHYL-PYRIDINE(124863-82-7)

Safety Data

• Hazardous Substances Data: 124863-82-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellowish Thick Oil

InChI:InChI=1/C25H38FNO2Si/c1-16(2)23-20(14-28)22(18-10-12-19(26)13-11-18)21(24(27-23)17(3)4)15-29-30(8,9)25(5,6)7/h10-13,16-17,28H,14-15H2,1-9H3

Upstream product

• 288-32-4 1H-imidazole 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 202857-36-1 3-(tert-butyldimethylsilyloxymethyl)-2,6-diisopropyl-4-(4-fluorophenyl)-5-methylsulfonyloxymethylpyridine 

Relevant articles and documents

Substituted biphenyls

Substituted biphenyls having glucagon receptor antagonistic activity. Claimed compounds have the formula wherein R1aand R1bindependently represent (C1-C6) alkyl; R2represents (C1-C10) alkyl or substituted (C1-C10) alkyl wherein the substituents are independently from 1 to 3 of —SR7; R7represents phenyl, or substituted phenyl wherein the substituents are independently 1-5 of halogen, trifluoromethyl, (C1-C6) alkyl, (C1-C6) alkoxy, nitro, cyano, or hydroxyl; R3represents substituted (C1-C6) alkyl wherein the substituents are 1-2 hydroxyl groups; G represents a substituent selected from the group consisting of halogen, (C1-C6) alkyl, and OR4wherein R4is H or (C1-C6) alkyl; and y is 0 or an integer of 1-3. Pharmaceutical compositions containing such compounds and methods of treatment of glucagon-mediated conditions by administering such compounds are also claimed.

CERTAIN 7-[2,6-DIISOPROPYL-4-PHENYL-5-LOWER ALKOXYMETHYL-PYRID-3-YL]-3,5-DIHYDROXY-6-ENOATES AND DERIVATIVES USEFUL FOR TREATING CIRCULATORY DISEASES

Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula (I) in which A, B, D and E can have varied meanings, X is -CH2-CH2 or -CH=CH-, and R is wherein R21 denotes hydrogen or alkyl and R22 denotes hydrogen, denotes alkyl, aryl or aralkyl, or denotes a cation, and their oxidation products