1248705-75-0

Basic information

• Product Name: diethyl 2-(1-(4-chlorophenyl)-2-cyano-3-(4-methoxyphenylamino)-3-oxopropyl)malonate
• CAS NO: 1248705-75-0
• Molecular Weight: 472.925
• Mol File: 1248705-75-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diethyl 2-(1-(4-chlorophenyl)-2-cyano-3-(4-methoxyphenylamino)-3-oxopropyl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2-(1-(4-chlorophenyl)-2-cyano-3-(4-methoxyphenylamino)-3-oxopropyl)malonate(1248705-75-0)
• EPA Substance Registry System: diethyl 2-(1-(4-chlorophenyl)-2-cyano-3-(4-methoxyphenylamino)-3-oxopropyl)malonate(1248705-75-0)

Safety Data

• Hazardous Substances Data: 1248705-75-0(Hazardous Substances Data)

Upstream product

• 5382-38-7 2-cyano-N-(4-methoxyphenyl)acetamide 
• 6827-40-3 diethyl 4-chlorobenzylidenemalonate 

Relevant articles and documents

Stereoselective synthesis of 2-carbamoyl-2-cyanocyclopropanecarboxylates by tandem oxidative cyclization and neighboring group-assisted decarboxylation

In this paper, we report a facile synthesis of 2-carbamoyl-2- cyanocyclopropanecarboxylates through a tandem iodosobenzene/tetrabutylammonium iodide-induced oxidative cyclization and a subsequent neighboring group-assisted decarboxylation of the Michael adducts of 2-cyanoacetamides with α,β-unsaturated malonates. This method affords the desired highly functionalized cyclopropanes in moderate to good yields and with excellent diastereoselectivities. In addition, the reaction proceeds smoothly under mild conditions and with good functional group tolerance.