124887-92-9Relevant academic research and scientific papers
The highly syn-selective Michael reaction of enamines with 2-(1-alkenyl)-1,3-dioxolan-2-ylium cations generated from 2,2-dimethoxyethyl 2-alkenoates in situ
Machida,Hashimoto,Saigo,Inoue,Hasegawa
, p. 3737 - 3752 (2007/12/18)
2,2-Dimethoxyethyl 2-alkenoates are easily transformed into 2-(1-alkenyl)-1,3-dioxolan-2-ylium cations in situ on the action of titanium tetrachloride, which react with enamines to predominantly give syn Michael adducts in good yields. This is the first example of such a high syn-selectivity for the Michael reaction of α,β-unsaturated ester derivatives with ketone enolate equivalents.
A Highly Syn-selective Michael Reaction of Enamines with α,β-Unsaturated Esters via Cationic Intermediates
Hashimoto, Yukihiko,Machida, Shigeru,Saigo, Kazuhiko,Inoue, Jun-ya,Hasegawa, Masaki
, p. 943 - 946 (2007/10/02)
An efficient and highly diastereoselective Michael addition of enamines with 2,2-dimethoxyethyl esters of α,β-unsaturated acids was achieved by using titanium(IV) chloride as an activator.
