124901-30-0

Upstream product

• 7065-46-5 3,3-dimethylbutanoic acid chloride 
• 108-98-5 thiophenol 
• 1070-83-3 tert-Butylacetic acid 

Downstream Products

• 73378-21-9 trans-3-tert-butyl-4-phenyloxetan-2-one 
• 131436-08-3 r-4-cyclohexyl-c-3,4-dimethyloxetan-2-one 
• 186521-97-1 3-tert-butyl-4-phenyloxetan-2-one 
• 124901-36-6 5-(2,2-Dimethyl-propyl)-2-methylsulfanyl-oxazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Beta-lactones as antibacterial agents

The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negativ

β-lactones as privileged structures for the active-site labeling of versatile bacterial enzyme classes

(Chemical Equation Presented) A chemical proteomic strategy has been applied directly to bacterial proteomes, and b-lactones have been identified as important natural product derivatives with a high affinity to various enzyme classes (see picture). This a

A Practical and Efficient Method for the Synthesis of β-Lactones

This paper describes a convenient one-step preparation of β-lactames based on the addition of thiol ester enolates to carbonyl compounds.Under the proper conditions the resulting aldolates undergo spontaneous cyclization to produce β-lactones in good to excellent yield.The new β-lactone synthesis provides access to 2-oxetanones with a variety of substituents and substitution patterns.In general, thiol ester enolates combine with carbonyl compounds to form the less sterically crowded β-lactone diasteromers, and in some cases the reaction proceeds with excellent stereoselectivity.In conjunction with the stereospecific decarboxylation of β-lactones, this chemistry also provides a very attractive approach to the synthesis of substituted alkenes.

A Novel Method of Synthesis of 2-Methylthio-1,3-oxazoles

A one-pot synthesis of 2-methylthio-1,3-oxazoles by a cyclocondensation reaction between dimethyl N-(ethoxycarbonylmethyl)iminodithiocarbonate and S-phenyl alkanethioates and thiobenzoates is described.The new procedure offers several advantages: easy access of the reagents, high selectivity, and facile introduction of different substitutions in the heterocyclic ring.