1249192-83-3Relevant articles and documents
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines
Lam, Thanh,Hilgers, Mark T.,Cunningham, Mark L.,Kwan, Bryan P.,Nelson, Kirk J.,Brown-Driver, Vickie,Ong, Voon,Trzoss, Michael,Hough, Grayson,Shaw, Karen Joy,Finn, John
, p. 651 - 668 (2014/03/21)
A new series of dihydrofolate reductase (DHFR) inhibitors, the 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines, were designed and optimized for antibacterial potency and enzyme selectivity. The most potent inhibitors in this series contained a five-membered