124921-76-2Relevant academic research and scientific papers
Synthesis and evaluation of peptidic maleimides as transglutaminase inhibitors
Halim, Dany,Caron, Karine,Keillor, Jeffrey W.
, p. 305 - 308 (2007/10/03)
A series of novel transglutaminase inhibitors was prepared, based on the scaffold of a commonly used peptide substrate and bearing an electrophilic maleimide group. These compounds were evaluated in vitro and shown to lead to irreversible inactivation of tissue transglutaminase. Comparison with inhibitors studied previously provides insight into the steric environment of the enzyme active site.
Artificial Molecular Anion Hosts. Synthesis of a Chiral Bicyclic Guanidinium Salt Serving as a Functionalized Anchor Group for Oxo Anions
Gleich, Alexander,Schmidtchen, Franz P.
, p. 907 - 915 (2007/10/02)
Starting from L-asparagine, the synthesis of the S,S-bis(hydroxymethyl)-substituted bicyclic guanidinium salt 3 is described, which is obtained in 20percent overall yield with a diastereomeric excess de >98percent.The guanidinium compound 3 may serve as a
