124932-14-5

Basic information

• Product Name: N-2-methoxyethyl 2-phenylacetamide
• Synonyms: N-2-methoxyethyl 2-phenylacetamide
• CAS NO: 124932-14-5
• Molecular Weight: 193.246
• Mol File: 124932-14-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-2-methoxyethyl 2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-2-methoxyethyl 2-phenylacetamide(124932-14-5)
• EPA Substance Registry System: N-2-methoxyethyl 2-phenylacetamide(124932-14-5)

Safety Data

• Hazardous Substances Data: 124932-14-5(Hazardous Substances Data)

Upstream product

• 103-80-0 phenylacetyl chloride 
• 109-85-3 2-methoxyethylamine 
• 101-41-7 benzeneacetic acid methyl ester 
• 28481-53-0 2-hydroxyethyl 2-phenylacetate 
• 103-82-2 phenylacetic acid 

Relevant articles and documents

Direct conversion of esters to secondary amides using Tin(II) reagents

We have developed tow new procedures for the direct conversion of esters to secondary amides. In our first procedure, secondary amides can be prepared in 83-98% yield starting from glycol esters. Addition of Sn[N(TMS)2]2 and a primary amine to the glycol ester generates an intermediate tin(II) akoxy amide, which delivers the amino group intramolecularly to give the amide. A second general procedure for the preparation of secondary amides starts with methyl esters. Treatment of methyl esters with a tin reagent derived from Sn[N(TMS)2]2, Me2NCH2CH2OH, and a primary amine yields secondary amides in 87-98% yield.

A CONVENIENT SYNTHESIS OF AMIDES FROM CARBOXYLIC ACIDS AND PRIMARY AMINES

A convenient method for the formation of carboxamides from carboxylic acids and primary amines in the presence of molecular sieves is described.This process is very chemoselective.