124939-03-3

Basic information

• Product Name: N-{1-[8-bromo-6-(2-chlorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl]ethyl}ethanesulfonamide
• Synonyms: N-{1-[8-bromo-6-(2-chlorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl]ethyl}ethanesulfonamide
• CAS NO: 124939-03-3
• Molecular Formula: C20H19BrClN5O2S
• Molecular Weight: 508.81916
• Mol File: 124939-03-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-{1-[8-bromo-6-(2-chlorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl]ethyl}ethanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{1-[8-bromo-6-(2-chlorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl]ethyl}ethanesulfonamide(124939-03-3)
• EPA Substance Registry System: N-{1-[8-bromo-6-(2-chlorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl]ethyl}ethanesulfonamide(124939-03-3)

Safety Data

• Hazardous Substances Data: 124939-03-3(Hazardous Substances Data)

Upstream product

• 117267-34-2 methyl 2-(ethanesulfonamido)propionate 
• 117267-38-6 2-(ethanesulfonamido)propionhydrazide 
• 87213-49-8 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-thione 

Relevant articles and documents

POTENTIAL ANXIOLYTICS AND HYPNOTICS: 1-(ALKANESULFONAMIDOALKYL)-6-ARYL-8-HALOGENO-s-TRIAZOLO-1,4-BENZODIAZEPINES AND RELATED COMPOUNDS

7-Chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-thione and its 5-(2-chlorophenyl) and 7-bromo-5-(2-chlorophenyl) analogoues were reacted with N-(methanesulfonyl)- and N-(ethanesulfonyl)glycine and -alanine hydrazides (X-XIII) in boiling butanol to give the title compounds Iabc-IVabc.The alanine-derived substances IIIabc and IVabc were characterized by 1H NMR spectra as mixtures of two diastereoisomers.Similar reactions of 5-methylimidazole-4-carboxylic acid hydrazide (XIV) gave the s-triazolo-1,4-benzodiazepines Vabc together with their ring-opened precursors XVI and XVII.The compounds prepared showed the activity profile of the anxiolytic and hypnotic 4H-s-triazolo-1,4-benzodiazepine derivatives.