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Usage

Uses

Used in Pharmaceutical Industry:
Dexfenfluramine was used as an appetite suppressant for weight loss management due to its ability to increase serotonin levels in the brain, leading to feelings of fullness and reduced appetite.
However, it is important to note that dexfenfluramine was withdrawn from the market due to safety concerns, specifically its association with heart valve damage and pulmonary hypertension (high blood pressure in the lungs). Consequently, dexfenfluramine is no longer utilized for weight loss and is considered a prohibited substance for medical use.

Upstream product

• 1132-68-9 L-4-fluorophenylalanine 

Downstream Products

• 882153-89-1 (S)-3-(4-fluorophenyl)-1-p-toluenesulfonyl-2-propanol 
• 152485-69-3 (-)-1-(4-fluoro-phenyl)-2-propanol 
• 882149-30-6 (S)-3-(4-fluorophenyl)-1,2-propanediol 

Relevant academic research and scientific papers

Biocatalytic racemization of aliphatic, arylaliphatic, and aromatic α-hydroxycarboxylic acids

Biocatalytic racemization of a range of aliphatic, (aryl)aliphatic, and aromatic α-hydroxycarboxylic acids was accomplished by using whole resting cells of a range of Lactobacillus spp. The mild (physiological) reaction conditions ensured an essentially "clean" isomerization in the absence of side reactions, such as elimination or decomposition. Whereas straight-chain aliphatic 2-hydroxy-carboxylic acids were racemized with excellent rates (up to 85% relative to lactate), steric hindrance was observed for branched-chain analogues. Good rates were observed for aryl-alkyl derivatives, such as 3-phenyllactic acid (up to 59%) and 4-phenyl-2-hydroxybutanoic acid (up to 47%). In addition, also mandelate and its o-chloro analogue were accepted at a fair rate (45%). This biocatalytic racemization represents an important tool for the deracemization of a number of pharmaceutically important building blocks.

Highly enantioselective stereo-inverting sec-alkylsulfatase activity of hyperthermophilic Archaea

rac-sec-Alkyl sulfate esters 1a-8a were resolved in low to excellent enantioselectivities with E-values up to > 200 using whole cells of aerobically-grown hyperthermophilic sulfur-metabolizers, such as Sulfolobus solfataricus DSM 1617, Sulfolobus shibatae DSM 5389 and, most notably, Sulfolobus acidocaldarius DSM 639. Significantly enhanced selectivities were obtained using cells grown on sucrose-enriched Brock-medium. The stereochemical course of this biohydrolysis was shown to proceed with strict inversion of configuration, thus the preferred (R)-enantiomers were converted into the corresponding (S)-sec-alcohols to furnish a homochiral product mixture. The Royal Society of Chemistry 2005.