1249974-01-3 Usage
Difluoroacetic acid derivative
A modification of the standard acetic acid molecule, with two fluorine atoms replacing two hydrogen atoms This indicates the presence of two fluorine atoms in the acetic acid structure, which can influence the compound's reactivity and properties.
3-cyanophenyl group attached to the alpha carbon
A cyano group (CN) is attached to a phenyl ring (a six-carbon ring with alternating single and double bonds), which is further connected to the alpha carbon (the carbon next to the carboxyl group) This functional group attachment can affect the compound's chemical reactivity and its potential applications.
Used in the synthesis of pharmaceuticals and agrochemicals
The compound serves as a building block for creating various drugs and agrochemicals This highlights the compound's importance in the development of new products in these industries.
Development of new materials
The compound can be used to create novel materials with unique properties This suggests that the compound has potential applications beyond pharmaceuticals and agrochemicals.
Versatile building block in organic synthesis
The compound can participate in various chemical reactions, making it a valuable component in organic synthesis This emphasizes the compound's utility in creating a wide range of products.
Potential applications in the pharmaceutical industry
The compound has possibilities for use in the development of new drugs for various therapeutic areas This indicates that the compound may contribute to the advancement of treatments for different medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1249974-01-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,9,9,7 and 4 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1249974-01:
(9*1)+(8*2)+(7*4)+(6*9)+(5*9)+(4*7)+(3*4)+(2*0)+(1*1)=193
193 % 10 = 3
So 1249974-01-3 is a valid CAS Registry Number.
1249974-01-3Relevant academic research and scientific papers
Synthetic method of aromatic ring group or aromatic heterocyclic tetrazole
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Paragraph 0055-0062; 0069, (2020/12/30)
The synthetic method comprises the following steps: (1) reacting 1.0 eq of ArI or HArI with 1.2 eq of ethyl 2, 2-difluoroacetate in the presence of DMSO as a solvent and 4.0 eq of Cu under the protection of nitrogen at 30 DEG C and 50 DEG C, and purifying to obtain a first intermediate compound; (2) dissolving 1.0 eq of the first intermediate compound in a mixed solvent of THF and water, adding 2.0 eq of LiOH, reacting at room temperature for 2 hours, spin-drying the solvent, adding HCl until the pH value is equal to 3, and filtering to obtain a second intermediate compound; and (3) reacting 1.0 eq of the second intermediate compound with 2.0 eq of diphenyl azide phosphate in the presence of 2.5 eq of triethylamine by taking tert-butyl alcohol as a solvent to generate aromatic ring group or aromatic heterocyclic tetrazole. The invention provides a novel synthetic method of aromatic ring group or aromatic heterocyclic tetrazole, wherein a target compound can be more conveniently obtained, and reagents participating in the reaction are low in toxicity, mild in reaction condition, simple and safe in aftertreatment, good in product quality and suitable for large-scale production.
A new method for aromatic difluoromethylation: Copper-catalyzed cross-coupling and decarboxylation sequence from aryl iodides
Fujikawa, Kenichi,Fujioka, Yasutaka,Kobayashi, Akira,Amii, Hideki
, p. 5560 - 5563 (2011/12/05)
A new methodology for aromatic difluoromethylation is described. Aryl iodides reacted with α-silyldifluoroacetates upon treatment with copper catalyst in DMSO or DME to give the corresponding aryldifluoroacetates in moderate to good yields. The subsequent hydrolysis of aryldifluoroacetates and KF-promoted decarboxylation afforded a variety of difluoromethyl aromatics.
