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125-69-9

125-69-9

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125-69-9 Usage

Originator

Symptom 1 ,Parke Davis,US,1977

Uses

Different sources of media describe the Uses of 125-69-9 differently. You can refer to the following data:
1. relieving cough
2. Cough and cold preparations, Antitussives, OTC cough medicine
3. It is used as a potentially useful NMDA receptor agonist. it is usually used as central nervous antitussive, cough suppressant. This is one of the most popular ingredients in over-the-counter cold and cough medications. Dextromethorphan hydrobromide may be added to other preparations to help treat pain and a variety of other disturbances as well. It is used as a pharmaceutical raw material.

Manufacturing Process

The methylation of 51.4 parts by weight of D,L-3-hydroxy-N-methylmorphinan is carried out with a methylating solution obtained from 51.5 parts by weight of phenyl-trimethylammonium-chloride. The D,L-3-methoxy-Nmethyl-morphinan is isolated in the form of its hydrobromide, which melts with 1 mol of water at 92°-94°C,without water at 239°-240°C. The base isolated from the aqueous solution by means of sodium carbonate melts at 81°-83°C.27.1 parts by weight of D,L-3-methoxy-N-methyl-morphinan base are dissolved with 15.0 parts by weight of D-tartaric acid in 150 parts by volume of hot alcohol. The solution is cooled and seeded with (+)-3-methoxy-Nmethyl-morphinan-tartrate.The (+)-form which is difficultly soluble in alcohol separates, is filtered by suction and washed with a little alcohol.[The (-)-form may be crystallized from the residue obtained by concentrating the mother liquor, separating therefrom as much as possible of the (+)-form and adding acetone].The (+)-3-methoxy-N-methyl-morphinan-tartrate melts with 1 mol of water at 195°-196°C [α]D20 =+30.6° (c = 1.5 in water). The (+) base melting at 108°-109°C may be obtained from the tartrate by means of sodium carbonate. The corresponding hydrobromide melts at 122°-124°C [α]D20 =+27.6° (c = 1.5 in water).

Brand name

Benylin DM (Parke-Davis); Dextromethorphan Hydrobromide OROS Tablets (Ciba-Geigy); Drixoral Cough (Schering-Plough HealthCare); PediaCare 1 (McNeil Consumer); Romilar (Hoffmann-LaRoche-International); St. Joseph Cough Syrup (Schering-Plough HealthCare).

Therapeutic Function

Antitussive

Check Digit Verification of cas no

The CAS Registry Mumber 125-69-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 5 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 125-69:
(5*1)+(4*2)+(3*5)+(2*6)+(1*9)=49
49 % 10 = 9
So 125-69-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1

125-69-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name Dextromethorphan Hydrobromide

1.2 Other means of identification

Product number -
Other names DEXTROMETHORPHAN HBR

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:125-69-9 SDS

125-69-9Upstream product

125-69-9Related news

Release of DEXTROMETHORPHAN HYDROBROMIDE (cas 125-69-9) from freeze-dried enzyme-degradable hydrogels09/25/2019

Dextromethorphan hydrobromide was incorporated into albumin-crosslinked polyvinylpyrrolidone hydrogels by equilibrating the gels in a saturated drug solution followed by freeze drying to entrap the drug in the network. Through freeze drying, highly porous hydrogels containing uniformly dispersed...detailed

NotesDetermination of Dextrorphan in Plasma and Evaluation of Bioavailability of DEXTROMETHORPHAN HYDROBROMIDE (cas 125-69-9) in Humans09/24/2019

A method is described for the estimation of dextrorphan, a metabolite of dextromethorphan, in plasma. The bioavailability of dextromethorphan hydrobromide after 30 mg po, as measured by the concentration of total (free and conjugated) dextrorphan in the plasma, was determined in six human volunt...detailed

Research ArticlesDetermination of DEXTROMETHORPHAN HYDROBROMIDE (cas 125-69-9) by high-performance liquid chromatography using ion-pair formation09/10/2019

The chromatographic retention behavior of dextromethorphan hydrobromide on an octadecylsilane column was investigated as a function of the pairing ion and the mobile phase composition. Dramatic increases in the capacity factor were observed with pairing ions containing more than eight carbons an...detailed

Estimation of the percolation thresholds in DEXTROMETHORPHAN HYDROBROMIDE (cas 125-69-9) matrices09/09/2019

Percolation theory is a multidisciplinary theory that studies chaotic systems. It has been applied in the pharmaceutical field since 1987. Knowledge of the percolation threshold — one of the most important concepts in percolation theory — results in a clear improvement of the solid dosage form...detailed

Effect of Salicylamide and Acetaminophen on DEXTROMETHORPHAN HYDROBROMIDE (cas 125-69-9) Metabolism: Possible Pharmacological Implications09/08/2019

The effect of salicylamide and acetaminophen on the metabolic fate of dextrorphan, the primary metabolite of dextromethorphan, was studied in vivo in the rat. Plasma dextrorphan levels were measured at 5-min intervals up to 20 min and at longer intervals up to 2 hr after dextromethorphan hydrobr...detailed