125-99-5 Usage
Originator
Pathilon,Burroughs-Wellcome,US,1955
Manufacturing Process
Acetophenone, paraformaldehyde and diethylamine are first reacted to give ω-
diethylaminopropiophenone. That is reacted with cyclohexylmagnesium
bromide to give 3-diethylamino-1-cyclohexyl-1-phenylpropanol-1.
To 1,320 parts of methyl isobutyl ketone is added 570 parts of 3-
diethylamino-1-cyclohexyl-1-phenylpropanol-1 (2 mols) and the mixture is
stirred until solution is complete. Then 500 parts (3.2 molsor 60% excess) of
ethyl iodide are added. After filtration, the filtrate is diluted with an additional
300 parts of methyl isobutyl ketone and the solution is then heated at the
reflux temperature (108°C to 110°C) for 9 hours. After cooling to 0°C, the
precipitated solid material is removed by filtration, washed with isopropyl
acetate and dried. Approximately 777 parts of product is obtained or a yield of 88.6% based on as-is starting material or 92.5% based on real starting
material.
Therapeutic Function
Anticholinergic
Check Digit Verification of cas no
The CAS Registry Mumber 125-99-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 125-99:
(5*1)+(4*2)+(3*5)+(2*9)+(1*9)=55
55 % 10 = 5
So 125-99-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H36NO.HI/c1-4-22(5-2,6-3)18-17-21(23,19-13-9-7-10-14-19)20-15-11-8-12-16-20;/h7,9-10,13-14,20,23H,4-6,8,11-12,15-18H2,1-3H3;1H/q+1;/p-1
