1250-97-1Relevant articles and documents
Dehalogenation methodof 9-halogenated steroid compound and application
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Paragraph 0164-0166, (2021/01/11)
The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the following steps: reacting a compound I with a hydrogen donor and an azo radical initiator to obtain a 9-dehalogenated product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, a hydrogen donor adopts one or a combination of more of hypophosphorous acid and hypophosphite, formic acid and formate, organic silicon hydride, hydrazine compounds or cyclohexene, and an initiator adopts an azo free radical initiator. Reagents such as chromium, divalent chromium salt, trivalent chromium salt or tributyltin hydride which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the method is green and environmentally friendly, the synthesis process is simple, convenient and easy to implement, and the production applicability is improved.
A process for the preparation of hydrocortisone acetate
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, (2017/03/08)
The invention discloses a preparation method of cortisone acetate, and belongs to the field of pharmaceutical chemistry. According to the method, 11 alpha-hydroxy- 16 alpha, 17 alpha-epoxy progesterone is used as a raw material to prepare the cortisone acetate through bromine reaction, debromination reaction, bromination reaction, replacement reaction and oxidation reaction. The method can effectively avoid the occurrence of side reactions, and improves the quality of the product; at the same time, iodine is replaced by low-cost bromine for halogenating reaction, the production cost is greatly reduced, the method is high in efficiency and low in energy consumption, and the product quality and yield are good.
New synthesis of cortico steroids from 17-Keto steroids: Application and stereochemical study of the unsaturated sulfoxide-sulfenate rearrangement
Van Rheenen,Shephard
, p. 1582 - 1584 (2007/10/13)
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