1250-97-1

Basic information

• Product Name: 11alpha,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate
• Synonyms: 11alpha,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate;Pregn-4-ene-11,17,21-triol-3,20-dione 21-acetate;21-Acetyloxy-11α,17-dihydroxypregn-4-ene-3,20-dione;Epi Hydrocortisone 21-Acetate;Epi Hydrocortisone 21-AcetateCAS Number:
• CAS NO: 1250-97-1
• Molecular Formula: C₂₃H₃₂O₆
• Molecular Weight: 404.49658
• EINECS: 215-008-1
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 1250-97-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 576.6°Cat760mmHg
• Flash Point: 196.2°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 1.08E-15mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: Refrigerator
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Sligh
• CAS DataBase Reference: 11alpha,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 11alpha,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate(1250-97-1)
• EPA Substance Registry System: 11alpha,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate(1250-97-1)

Safety Data

• Hazardous Substances Data: 1250-97-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
11alpha,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate is used as a Hydrocortisone (H714620) analogue for its glucocorticoid properties. It is utilized in the development of pharmaceutical products to treat various conditions that may benefit from the anti-inflammatory and immunosuppressive effects of glucocorticoids.

InChI:InChI=1/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18+,20+,21-,22-,23-/m0/s1

Upstream product

• 603-98-5 11α,17α-dihydroxypregn-4-ene-3,20-dione 
• 3684-83-1 11α-hydroxy-16α,17α-epoxyprogesterone 
• 127-08-2 potassium acetate 
• 103782-07-6 11α,17α-dihydroxy-21-bromo progesterone 
• 566-35-8 Epicortisol 
• 141-78-6 ethyl acetate 
• 50-23-7 cortisol 
• 108-24-7 acetic anhydride 

Downstream Products

• 50-04-4 Cortisone acetate 

Relevant articles and documents

Dehalogenation methodof 9-halogenated steroid compound and application

The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the following steps: reacting a compound I with a hydrogen donor and an azo radical initiator to obtain a 9-dehalogenated product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, a hydrogen donor adopts one or a combination of more of hypophosphorous acid and hypophosphite, formic acid and formate, organic silicon hydride, hydrazine compounds or cyclohexene, and an initiator adopts an azo free radical initiator. Reagents such as chromium, divalent chromium salt, trivalent chromium salt or tributyltin hydride which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the method is green and environmentally friendly, the synthesis process is simple, convenient and easy to implement, and the production applicability is improved.

Preparation process of hydrocortisone acetate

The invention relates to a preparation process of hydrocortisone acetate. The preparation process comprises the following steps: under the action of 4-dimethylamiopryidine, enabling hydrocortisone and acetic anhydride to directly react, without the need of additionally utilizing a solvent; washing into water and separating out materials; filtering and drying to prepare the hydrocortisone acetate. The technical problem in the prior art that a reaction process commonly needs pyridine or a pyridine substitute solvent is overcome; the large-batch production capability of a reaction kettle is greatly improved and a condition that a lot of industrial wastewater difficult to treat is generated is avoided. The preparation process has a simple process, is good for environment protection, is low in cost and is suitable for industrial large-scale production.

A process for the preparation of hydrocortisone acetate

The invention discloses a preparation method of cortisone acetate, and belongs to the field of pharmaceutical chemistry. According to the method, 11 alpha-hydroxy- 16 alpha, 17 alpha-epoxy progesterone is used as a raw material to prepare the cortisone acetate through bromine reaction, debromination reaction, bromination reaction, replacement reaction and oxidation reaction. The method can effectively avoid the occurrence of side reactions, and improves the quality of the product; at the same time, iodine is replaced by low-cost bromine for halogenating reaction, the production cost is greatly reduced, the method is high in efficiency and low in energy consumption, and the product quality and yield are good.

A green method for selective acetylation of primary alcohols using ethyl acetate and solid potassium carbonate

A simple and selective acetylation of primary alcohols in the presence of other reactive functionalities such as secondary alcohol, phenol, acetonide and amine is described using mild ethyl acetate as the acetyl-transfer agent and solid potassium carbonate as the catalyst.