1250126-35-2

Upstream product

• 504-29-0 2-aminopyridine 
• 620-19-9 1-chloromethyl-3-methyl-benzene 
• 587-03-1 3-methylbenzyl alcohol 
• 1445435-67-5 C₁₈H₂₂N₂O₂ 
• 38427-94-0 N-(tert-butoxycarbonyl)-2-aminopyridine 

Downstream Products

• 1243272-98-1 7-methylbenzo[4,5]imidazo[1,2-a]pyridine 
• 474537-07-0 9-methylpyrido[1,2-a]benzimidazole 

Relevant academic research and scientific papers

Isoxazole-containing pyridopyrimidinone compound as well as preparation method and application thereof

The invention relates to an isoxazole-containing pyridinopyrimidinone compound as well as a preparation method and application thereof. The compound disclosed by the invention has a structure shown as a formula (I), has excellent insecticidal activity on sogatella furcifera, brown planthopper and the like, and can be used for medicines or agents for preventing and treating hemiptera pests such as rice planthoppers and aphids. The structure and the preparation process are simple, and the production cost is low.

A borrowing hydrogen methodology: Palladium-catalyzed dehydrative: N -benzylation of 2-aminopyridines in water

We demonstrate a greener borrowing hydrogen methodology using the π-benzylpalladium system, which offers an efficient and environmentally friendly dehydrative N-monobenzylation of 2-aminopyridines with benzylic alcohols in the absence of base. The crossover experiment using benzyl-α,α-d2 alcohol and 3-methylbenzyl alcohol afforded H/D scrambled products, suggesting that the dehydrative N-benzylation in our catalytic system involves a borrowing hydrogen pathway. KIE experiments show that C-H bond cleavage at the benzylic position of benzyl alcohol is involved in the rate-determining step (KIE = 2.9). This simple base-free protocol can be achieved under mild conditions in an atom-economic process, affording the desired products in moderate to excellent yields.

A metal-free tandem demethylenation/C(sp2)-H cycloamination process of N -Benzyl-2-aminopyridines via C-C and C-N bond cleavage

A mild, metal-free synthesis of pyrido[1,2-a]benzimidazoles starting with N-benzyl-2-aminopyridines, which employs PhI(OPiv)2 as a stoichiometric oxidant, has been developed. The process is initiated by an unusual PhI(OPiv)2-mediated ipso SEAr reaction, followed by solvent-assisted C-C and C-N bond cleavage.