1250244-71-3

Upstream product

• 705942-68-3 (1S,2S)-2-(2-Methoxy-phenyl)-cyclopent-3-enol 
• 60895-01-4 3(S)-acetoxy-5-(R)-hydroxy-cyclopent-1-ene 
• 285-67-6 Cyclopentene oxide 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 68516-52-9 2-methoxyphenylmagnesium chloride 

Downstream Products

• 2702-89-8 2-(2-methoxyphenyl)cyclopentanone 
• 1392108-39-2 methyl 3-(2-methoxyphenyl)-2-oxocyclopentanecarboxylate 
• 1392108-40-5 7-(2-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diol 
• 1392108-38-1 2,4-dichloro-7-(2-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine 
• 1392108-41-6 2-chloro-7-(2-methoxyphenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine 
• 1392107-35-5 (R)-2-methoxy-4-[7-(2-methoxyphenyl)-4-(methylamino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-ylamino]benzonitrile 
• 1392107-34-4 (S)-2-methoxy-4-[7-(2-methoxyphenyl)-4-(methylamino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-ylamino]benzonitrile 

Relevant academic research and scientific papers

Palladium-catalyzed reaction of 4-cyclopentene-1,3-diol monoacetate with Grignard reagents producing hitherto unreachable cis-1,2-isomers

Reaction of 4-cyclopentene-1,3-diol monoacetate with RMgCl (R = alkyl, aryl) in the presence of a palladium catalyst proceeded with retention of configuration to give cis-1,2-regio-isomers as the major products.

COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION

The present disclosure provides a series of compounds of the formula (I), which modulate β-amyloid peptide (β-ΑΡ) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-ΑΡ) production.