125030-71-9

Basic information

• Product Name: 5-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]prop-2-yn-1-yl}phenanthridin-6(5H)-one
• Synonyms: 5-(3-(4-(2-Chlorophenyl)-9-methyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-2-yl)-2-propynyl)phenanthridin-6(5H)-one; 6(5H)-Phenanthridinone, 5-(3-(4-(2-chlorophenyl)-9-methyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-2-yl)-2-propynyl)-
• CAS NO: 125030-71-9
• Molecular Formula: C₃₁H₂₀ClN₅OS
• Molecular Weight: 546.0414
• Mol File: 125030-71-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 819.6°C at 760 mmHg
• Flash Point: 449.5°C
• Density: 1.41g/cm³
• Vapor Pressure: 5.81E-27mmHg at 25°C
• Refractive Index: 1.749
• CAS DataBase Reference: 5-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]prop-2-yn-1-yl}phenanthridin-6(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]prop-2-yn-1-yl}phenanthridin-6(5H)-one(125030-71-9)
• EPA Substance Registry System: 5-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]prop-2-yn-1-yl}phenanthridin-6(5H)-one(125030-71-9)

Safety Data

• Hazardous Substances Data: 125030-71-9(Hazardous Substances Data)

Upstream product

• 36811-58-2 5-(2-chlorophenyl)-1,3-dihydro-2H-thieno[2,3-e][4,1]diazepin-2-one 
• 67860-47-3 5-(2-chlorophenyl)-1,3-dihydro-7-iodo-2H-thieno<2,3-e><1,4>diazepin-2-thione 
• 1015-89-0 6(5H)-phenanthridinone 
• 67860-41-7 4-(2-chlorophenyl)2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine 
• 37045-22-0 N-propargyl-6(5H)-phenanthridinone 

Downstream Products

• 125031-05-2 Acetic acid 4-(2-chloro-phenyl)-9-methyl-2-[3-(6-oxo-6H-phenanthridin-5-yl)-prop-1-ynyl]-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl ester 
• 125031-26-7 5-{3-[4-(2-Chloro-phenyl)-6-hydroxy-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-prop-2-ynyl}-5H-phenanthridin-6-one 
• 125031-04-1 5-{3-[4-(2-Chloro-phenyl)-9-methyl-5-oxy-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-prop-2-ynyl}-5H-phenanthridin-6-one 

Relevant articles and documents

Triazolobenzo- and triazolothienodiazepines as potent antagonists of platelet activating factor

A series of [1,2,4]triazolo[4,3-α][1,4]benzodiazepines bearing an ethynyl functionality at the 8-position and the isosteric thieno[3,2-f][1,2,4]triazolo[4,3-α][1,4]diazepines were prepared and evaluated as antagonists of platelet activating factor. The effects of substitution were explored in in vitro and in vivo test systems designed to measured PAF-antagonistic activity. Results are discussed and compared with previously published data. Many of the compounds had activity superior to WEB 2086, compound 1. In general, the thieno analogues exhibited better oral activity than the corresponding benzodiazepines. The duration of activity upon oral administration was modulated by the substitution on the acetylenic side chain. Compounds 71 and 81 were selected for further pharmacological evaluation as a result of their good oral potency and exceptionally long duration of action.