125031-47-2

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-oxo-6-phenyl-1,2-dihydropyridine-3-carboxylate is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is utilized for the production of medications targeting various diseases and conditions due to its potential biological activities, such as anti-inflammatory, antioxidant, and antimicrobial properties.

Upstream product

• 115262-07-2 2-methyl-N-(1-phenylethylidene)propan-2-amine 
• 22398-14-7 dimethyl (methoxymethylene)malonate 
• 888721-10-6 methyl 2-oxo-2H-[1,2'-bipyridine]-3-carboxylate 
• 1202163-24-3 methyl 2-carbamoyl-5-dimethylamino-5-phenylpentane-2,4-dienoate 

Downstream Products

• 56162-63-1 2-oxo-6-phenyl-1,2-dihydropyridine-3-carboxylic acid 
• 1202163-27-6 methyl 5-bromo-2-oxo-6-phenyl-1,2-dihydropyridine-3-carboxylate 
• 1202164-41-7 tert-butyl 2-(4-((2-methoxy-6-phenylpyridin-3-yl)methoxy)phenoxy)-ethanoate 
• 1202162-73-9 2-(4-(((2-methoxy-6-phenylpyridin-3yl)methyl)amino)phenoxy)ethanoic acid 
• 1202164-04-2 tert-butyl 2-(4-(((2-methoxy-6-phenylpyridin-3-yl)methyl)amino)-phenoxy)ethanoate 
• 1202163-75-4 2-methoxy-6-phenylnicotinaldehyde 
• 1202163-74-3 3-(bromomethyl)-2-methoxy-6-phenylpyridine 
• 1202163-73-2 (2-methoxy-6-phenylpyridin-3-yl)methyl 4-methylbenzenesulfonate 
• 1202163-53-8 (2-methoxy-6-phenylpyridin-3-yl)methanol 
• 1202163-51-6 methyl 2-phenylthio-6-phenyl-pyridine-3-carboxylate 
• 1202163-50-5 methyl 2-(piperidin-1-yl)-6-phenyl-pyridine-3-carboxylate 
• 275384-67-3 2-chloro-6-phenylpyridine-3-carboxylic acid methyl ester 
• 85815-01-6 methyl 2-methoxy-6-phenyl-pyridine-3-carboxylate 
• 1037086-01-3 methyl 1-benzyl-2-oxo-6-phenyl-1,2-dihydropyridine-3-carboxylate 

Relevant academic research and scientific papers

Rhodium-Catalyzed C4-Selective C-H Alkenylation of 2-Pyridones by Traceless Directing Group Strategy

A rhodium-catalyzed C4-selective C-H alkenylation of 3-carboxy-2-pyridones with styrenes has been developed. The carboxylic group at the C3 position works as the traceless directing group, and the corresponding C4-alkenylated 2-pyridones are obtained exclusively with concomitant decarboxylation. Unlike the reported procedures, the exclusive C4 selectivity is uniformly observed even in the presence of potentially more reactive C-H bonds at the C5 and C6 positions. By using this strategy, the multiply substituted 2-pyridone can be prepared via sequential C-H functionalization reactions.

PPAR AGONIST COMPOUNDS, PREPARATION AND USES

The present invention relates to novel PPAR agonist compounds as well as pharmaceutical compositions containing them. The compounds according to the invention are of quite particular therapeutic interest, notably for treating diabetes and/or dyslipidemias, as well as for preventing cardiovascular pathologies.

An efficient synthesis of functionalized 2-pyridones by direct route or via amide/enolate ammonium salt intermediates

A number of compounds with a 2-pyridone structure 3, which have different substituents and-are analogous to cardiotonic drugs like milrinone, have been synthesized in high yields from the appropriate enamino ketones 2 using different cyanomethylene active compounds (methyl cyanoacetate, benzoylacetonitrile and phenylsulfonylacetonitrile). In this synthetic route, the active role of the dimethylamine released in situ on the cyclization process has been underlined. In particular, its direct intervention; as a nucleophile or a base, was proven and intermediate amides 5 or enolate ammonium salts 6 were isolated and recognized by the analytical and spectral data.

A New Route to 2-Amino- or 2-Hydroxy-3-pyridinecarboxylic Acid Derivatives

Schiff's bases derived from ketones and t-butylamine (1) reacted with methyl methoxymethylenemalonate to give 2-hydroxy-3-pyridinecarboxylates.Similarly, treatment of 1 with ethoxymethylenemalononitrile gave 2-amino-3-pyridinecarbonitriles.Compounds 1 on reaction with ethyl 2-cyano-3-ethoxypropenoate afforded 2-amino-3-pyridinecarboxylates.