1250447-98-3Relevant academic research and scientific papers
A highly enantio- and diastereoselective direct aldol reaction in aqueous medium catalyzed by thiazolidine-based compounds
Rambo, Raoní Scheibler,Gross Jacoby, Caroline,Da Silva, Tiago Lima,Schneider, Paulo Henrique
, p. 632 - 637 (2015)
Taking l-aminoacids as starting materials, a new set of enantiopure thiazolidine-based organocatalysts were prepared using a simple synthetic approach and successfully applied in the asymmetric direct aldol reaction between various cyclic ketones and aldehydes in a saturated aqueous medium. The aldol adducts were obtained with excellent enantioselectivity (up to >99% ee) and diastereoselectivity (dr >20:1).
Thiazolidine-based organocatalysts for a highly enantioselective direct aldol reaction
Rambo, Raoni S.,Schneider, Paulo H.
experimental part, p. 2254 - 2257 (2010/11/03)
A set of enantiopure thiazolidine-based organocatalysts have been synthesized from l-cysteine, in a straightforward manner allowing numerous structural variations. In particular, organocatalyst 3a exhibits the highest catalytic performance working in an a
